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Pregnancy Does Not Worsen Outcomes in Triple-Negative Breast Cancer
When compared to patients with triple-negative breast cancer, patients with pregnancy-associated TNBC do not experience a worse recurrence rate nor overall survival, according to research in The Breast.
Patients had a diagnosis of both triple-negative pregnancy-associated breast cancer (TN-PABC) and triple-negative non-pregnancy-associated breast cancer under age 46, between January 2005 and December 2020.
After propensity score matching for tumor size and lymph node involvement, there were 59 patients in each group.
Eight recurrences occurred in the TN-PABC group and 10 in the triple negative non-pregnancy-associated breast cancer group. Two patients died in the TN-PABC group and 6 in the non-pregnancy-associated TNBC group.
All patients with TN-PABC diagnosed in their second and third trimesters continued their pregnancy and gave birth to healthy newborns with a median gestational age at delivery of 38 weeks.
TNBC is often associated with a poor prognosis in pregnant patients due to advanced stage at diagnosis and high lymph node involvement, according to researchers.
The study results show that pregnancy did not worsen prognosis in terms of recurrence and overall survival in patients with TNBC.
Reference: https://www.thebreastonline.com/article/S0960-9776(22)00004-2/fulltext
Disclosures: No authors declared financial ties to drugmakers.
By MD /alert Staff
Patients had a diagnosis of both triple-negative pregnancy-associated breast cancer (TN-PABC) and triple-negative non-pregnancy-associated breast cancer under age 46, between January 2005 and December 2020.
After propensity score matching for tumor size and lymph node involvement, there were 59 patients in each group.
Eight recurrences occurred in the TN-PABC group and 10 in the triple negative non-pregnancy-associated breast cancer group. Two patients died in the TN-PABC group and 6 in the non-pregnancy-associated TNBC group.
All patients with TN-PABC diagnosed in their second and third trimesters continued their pregnancy and gave birth to healthy newborns with a median gestational age at delivery of 38 weeks.
TNBC is often associated with a poor prognosis in pregnant patients due to advanced stage at diagnosis and high lymph node involvement, according to researchers.
The study results show that pregnancy did not worsen prognosis in terms of recurrence and overall survival in patients with TNBC.
Reference: https://www.thebreastonline.com/article/S0960-9776(22)00004-2/fulltext
Disclosures: No authors declared financial ties to drugmakers.
By MD /alert Staff