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FDA Clears First Clinical Trial for Breast Cancer Vaccine

Pembrolizumab + Chemotherapy Beneficial in Triple-Negative Breast Cancer

In previous research, pembrolizumab has shown potential as a treatment for patients with triple-negative breast cancer.

The results of the KEYNOTE-355 trial, evaluating pembrolizumab in combination with chemotherapy, were presented at the 2020 ASCO Virtual Annual Meeting.

Lead study author Javier Cortes, MD, PhD, of the IOB Institute of Oncology told MD/ alert, that the trial results could eventually lead to the combination therapy being the new standard of care for triple negative breast cancer.

“The role of immunotherapy in triple-negative breast cancer seems to be more and more obvious with time, and the addition of chemotherapy makes a lot of sense because of the ability to release a number of mutations that might be seen by the immune system,” Dr Cortes said. “It’s also well known that many triple-negative breast cancer patients express PDL1+, which is one of the most important targets in terms of the immune checkpoint inhibitors.”

By Adam Hochron

Next Up In Breast Cancer

Greater Weight Loss Among Women with Breast Cancer After Phone-Based Coaching

Greater Weight Loss Among Women with Breast Cancer After Phone-Based Coaching

Pertuzumab, Trastuzumab Combination Effective in HER2+ Metastatic Breast Cancer

Pertuzumab, Trastuzumab Combination Effective in HER2+ Metastatic Breast Cancer

HER3-DXd Promotes Clinical Activity in MBC at Varying HER3 Expression Levels

HER3-DXd Promotes Clinical Activity in MBC at Varying HER3 Expression Levels

Capecitabine Has Less Toxicity, Similar Survival in Metastatic Breast Cancer with Fixed Dose

Capecitabine Has Less Toxicity, Similar Survival in Metastatic Breast Cancer with Fixed Dose

ASCO, SSO Publish Guidelines for Germline Mutation Testing in Breast Cancer

ASCO, SSO Publish Guidelines for Germline Mutation Testing in Breast Cancer

Younger Postmenopausal Patients May Skip Adjuvant Radiotherapy After Early Breast Cancer Surgery

Younger Postmenopausal Patients May Skip Adjuvant Radiotherapy After Early Breast Cancer Surgery

NCCN Clinical Practice Guidelines Recommend FES PET Imaging for ER+ Breast Cancer

NCCN Clinical Practice Guidelines Recommend FES PET Imaging for ER+ Breast Cancer

PET-CT Scanning Improves Detection of Metastases in Patients With Locally Advanced Breast Cancer

PET-CT Scanning Improves Detection of Metastases in Patients With Locally Advanced Breast Cancer

Sacituzumab Govitecan Improves OS in Endocrine-Resistant Metastatic Breast Cancer

Sacituzumab Govitecan Improves OS in Endocrine-Resistant Metastatic Breast Cancer

Less Frequent Mammography for Breast Cancer Survivors Has No Impact on Survival

Less Frequent Mammography for Breast Cancer Survivors Has No Impact on Survival

Breast Cancer Index Risk Scores a Prognostic Indicator of Overall, Late Distant Recurrence

Breast Cancer Index Risk Scores a Prognostic Indicator of Overall, Late Distant Recurrence

Patients with Breast Cancer That Converts from Lymph Node-Positive to -Negative Can Skip Adjuvant Irradiation

Patients with Breast Cancer That Converts from Lymph Node-Positive to -Negative Can Skip Adjuvant Irradiation

Donepezil Does Not Improve Cancer-Related Cognitive Impairment in Breast Cancer Survivors

Donepezil Does Not Improve Cancer-Related Cognitive Impairment in Breast Cancer Survivors

Fertility Preservation Safe for Patients Who Pause HR-positive Breast Cancer Endocrine Therapy to Conceive

Fertility Preservation Safe for Patients Who Pause HR-positive Breast Cancer Endocrine Therapy to Conceive

Tucatinib Plus Trastuzumab Emtansine Extend PFS in Late-Stage HER2-Positive Breast Cancer

Tucatinib Plus Trastuzumab Emtansine Extend PFS in Late-Stage HER2-Positive Breast Cancer

Neratinib + Capecitabine Improves QoL for HER2+ Metastatic Breast Cancer

Neratinib + Capecitabine Improves QoL for HER2+ Metastatic Breast Cancer

Large Epidemiology Study Updates Breast Cancer Risk for Women Lacking Family History

Large Epidemiology Study Updates Breast Cancer Risk for Women Lacking Family History

ASCO Updates Guidelines for Systemic Therapy in Advanced HER2+ Breast Cancer

ASCO Updates Guidelines for Systemic Therapy in Advanced HER2+ Breast Cancer

European Regulators Validate TNBC Biologic Treatment Application

European Regulators Validate TNBC Biologic Treatment Application

Zanidatamab-Docetaxel Effective as First-Line Therapy in Advanced HER2+ Breast Cancer

Zanidatamab-Docetaxel Effective as First-Line Therapy in Advanced HER2+ Breast Cancer

FDA Grants Fast Track Designation in HR+/HER2- Metastatic Breast Cancer

FDA Grants Fast Track Designation in HR+/HER2- Metastatic Breast Cancer

Study Shows Breastfeeding Can be Safe for Breast Cancer Survivors

Study Shows Breastfeeding Can be Safe for Breast Cancer Survivors

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Olaparib Recommended for European Approval for Patients with High-Risk Early Breast Cancer

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Research Shows Benefits of Pembrolizumab as Single Agent TNBC Treatment

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Genomic Profiling Improves Metastatic Breast Cancer Research

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20-Year Benefit from Endocrine Therapy in Premenopausal Patients with Breast Cancer

New Test May Detect Multiple Cancers, Tumor Points of Origin

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Various Breast Cancer Research Challenges in Recurrence, Triple Negative BC

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FDA Grants Bria-IMT Immunotherapy for Metastatic Breast Cancer Fast Track Status

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Palbociclib Combination Fails to Extend Overall Survival for Advanced Breast Cancer

The Metastatic Spread of Breast Cancer Accelerates During Sleep

The Metastatic Spread of Breast Cancer Accelerates During Sleep

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No Benefit with Early Local Therapy In De Novo Metastatic Breast Cancer

Camizestrant Improves PFS in Patients with HR+/HER2– Breast Cancer

Camizestrant Improves PFS in Patients with HR+/HER2– Breast Cancer

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Metastatic Breast Cancer: "The Journey Begins"

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Improving Outcomes for Early Onset Breast Cancer

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Researchers Identify Target of Metastasis in Triple-Negative Breast Cancer

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Abemaciclib Represents ‘New Standard of Care’ for Patients With High-Risk Early Breast Cancer

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Pertuzumab-Based Regimen Continues to Reduce Recurrence in Patients with Early Breast Cancer

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Pembrolizumab + Chemotherapy Beneficial in Triple-Negative Breast Cancer

1:25 MD /Alert Exclusive

FDA Clears First Clinical Trial for Breast Cancer Vaccine

Protein Coding Gene Enhances Cisplatin Resistance in Triple-Negative Breast Cancer

Protein Coding Gene Enhances Cisplatin Resistance in Triple-Negative Breast Cancer

Going the Distance With Metastatic Breast Cancer: 'Personal Best'

Going the Distance With Metastatic Breast Cancer: "Personal Best"

FDA Approves Biosimilar Treatment for Cancer-Related Neutropenia

FDA Approves Biosimilar Treatment for Cancer-Related Neutropenia

Some Patients with Invasive Breast Cancer Can Skip Surgery

Some Patients with Invasive Breast Cancer Can Skip Surgery

Trastuzumab Deruxtecan Significantly Improves OS, PFS in Patients with MBC

Trastuzumab Deruxtecan Significantly Improves OS, PFS in Patients with MBC

ASCO Guideline on Adjuvant Olaparib in Patients with HER2-negative Breast Cancer

ASCO Guideline on Adjuvant Olaparib in Patients with HER2-negative Breast Cancer

Capivasertib, Fulvestrant Improves PFS in Patients with HR+/HER2– Breast Cancer

Capivasertib, Fulvestrant Improves PFS in Patients with HR+/HER2– Breast Cancer

New Uses for Existing Therapies in Breast Cancer Research

New Uses for Existing Therapies in Breast Cancer Research

European Commission Approves Trastuzumab Deruxtecan for Second-Line HER2+ Breast Cancer

European Commission Approves Trastuzumab Deruxtecan for Second-Line HER2+ Breast Cancer

FDA Approves AI Algorithms for Breast Cancer Detection

FDA Approves AI Algorithms for Breast Cancer Detection

Combining Eribulin and Pembrolizumab in Metastatic Triple-Negative Breast Cancer

Combining Eribulin and Pembrolizumab in Metastatic Triple-Negative Breast Cancer

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FDA Issues Warning Alert for Atezolizumab/Paclitaxel Combo in TNBC

Why Dual Light Therapy Hits Triple Negative Breast Cancer Harder

Why Dual Light Therapy Hits Triple Negative Breast Cancer Harder

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Celecoxib Shows No Benefit for Patients with Early Breast Cancer

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Trastuzumab Deruxtecan Improves Survival in HER2-Positive Breast Cancer

FDA Approves Diagnostic to Identify Microsatellite Instability-High Solid Tumors

FDA Approves Diagnostic to Identify Microsatellite Instability-High Solid Tumors

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Inflammatory Markers May Predict Frailty After Chemotherapy

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Metastatic Breast Cancer Therapy Gains Fast Track Designation

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Understanding Recent Breast Cancer Vaccine Breakthroughs

Ribociclib, Endocrine Therapy Combination Improves PFS in Aggressive Breast Cancer

Ribociclib, Endocrine Therapy Combination Improves PFS in Aggressive Breast Cancer

Sacituzumab Govitecan Extends Survival in Metastatic Triple-Negative Breast Cancer

Sacituzumab Govitecan Extends Survival in Metastatic Triple-Negative Breast Cancer

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No OS Benefit with Margetuximab Over Trastuzumab in Previously Treated HER2+ Breast Cancer

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Combination Therapy Fails to Meet Primary Endpoints in HR+ HER2- Breast Cancer Treatment

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Impassion031 Outcomes Show Importance of Looking Beyond Initial Trial Data

Endocrine Therapy Noninferior to Chemotherapy as First-Line Treatment for Patients with MBC

Endocrine Therapy Noninferior to Chemotherapy as First-Line Treatment for Patients with MBC

Neratinib and Capecitabine Improves PFS in HER2+ Metastatic Breast Cancer

Neratinib and Capecitabine Improves PFS in HER2+ Metastatic Breast Cancer

Trastuzumab Deruxtecan Highly Effective in Patients with HER2-Low Metastatic Breast Cancer

Trastuzumab Deruxtecan Highly Effective in Patients with HER2-Low Metastatic Breast Cancer

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Time to Treatment Completion Associated with Poor Breast Cancer Survival

New Vaccine to Prevent Breast Cancer in Early Clinical Trials

New Vaccine to Prevent Breast Cancer in Early Clinical Trials

Mindfulness Shows Benefits for Young Breast Cancer

Mindfulness Shows Benefits for Young Breast Cancer

New ASCO, ASTRO, SSO Joint Clinical Guidelines for Hereditary Breast Cancer

New ASCO, ASTRO, SSO Joint Clinical Guidelines for Hereditary Breast Cancer

FDA Approves Trastuzumab Deruxtecan for HER2-Low Breast Cancer

FDA Approves Trastuzumab Deruxtecan for HER2-Low Breast Cancer

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Clinical Trials Need Better Representation Among Black Patients

Treatment Combination Reduces Recurrence in Early-Stage Breast Cancer

Treatment Combination Reduces Recurrence in Early-Stage Breast Cancer

Therapy Targeting Inducible Nitric Oxide Signaling Shows Promise in TNBC

Therapy Targeting Inducible Nitric Oxide Signaling Shows Promise in TNBC

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Oncologist Explains How Gammapod Works for Breast Cancer

Durvalumab Provokes Robust Long-Term Outcomes in Patients with TNBC

Durvalumab Provokes Robust Long-Term Outcomes in Patients with TNBC

Plasmid DNA Vaccine Shows Promise in Patients with Advanced-Stage ERBB2+ Breast Cancer

Plasmid DNA Vaccine Shows Promise in Patients with Advanced-Stage ERBB2+ Breast Cancer

Nobel Prize Winner Links Cancer Immunotherapy to Programmed Cell Death Gene

Nobel Prize Winner Links Cancer Immunotherapy to Programmed Cell Death Gene

Breast Cancer Clinical Trial Fails to Meet Primary Endpoint

Breast Cancer Clinical Trial Fails to Meet Primary Endpoint

FDA Accepts Biologics License Application for New Metastatic HER2+ Breast Cancer Treatment

FDA Accepts Biologics License Application for New Metastatic HER2+ Breast Cancer Treatment

FDA Approval in BRCA Mutated HER2-negative High-Risk Early Breast Cancer

FDA Approval in BRCA Mutated HER2-negative High-Risk Early Breast Cancer

FDA Rejects Breast Cancer Therapy Due to Safety Concerns

FDA Rejects Breast Cancer Therapy Due to Safety Concerns

FDA Gives Priority Review for HR+, HER2– Advanced Breast Cancer Therapy

FDA Gives Priority Review for HR+, HER2– Advanced Breast Cancer Therapy

Advanced ER+ HER2+ Breast Cancer Combo Therapy Fails to Improve Outcomes

Advanced ER+ HER2+ Breast Cancer Combo Therapy Fails to Improve Outcomes

Chemotherapy Plus Treatment Combination for ERBB2-positive MBC Inferior in Clinical Practice

Chemotherapy Plus Treatment Combination for ERBB2-positive MBC Inferior in Clinical Practice

FDA Approves Companion Diagnostic for Patients with Breast Cancer, Low HER2 Expression

FDA Approves Companion Diagnostic for Patients with Breast Cancer, Low HER2 Expression

FDA Approves Combo of Abemaciclib, Endocrine Therapy for Early Breast Cancer

FDA Approves Combo of Abemaciclib, Endocrine Therapy for Early Breast Cancer

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FDA Grants Fast Track Designation to Novel Treatment in Breast Cancer

Helping Breast Cancer Oncologists Work ‘In the Trenches’

Helping Breast Cancer Oncologists Work ‘In the Trenches’

ICI-Related Major Adverse Cardiac Events Rare, but Cause Significant Morbidity

ICI-Related Major Adverse Cardiac Events Rare, but Cause Significant Morbidity

Study of Immunotherapy Combinations for Patients with Metastatic Breast Cancer

Study of Immunotherapy Combinations for Patients with Metastatic Breast Cancer

Integrating Tailored Therapy in Early, High-Risk Breast Cancer

Integrating Tailored Therapy in Early, High-Risk Breast Cancer

Neoadjuvant Amcenestrant Shows Robust Response in Postmenopausal ER+/HER2- Breast Cancer

Neoadjuvant Amcenestrant Shows Robust Response in Postmenopausal ER+/HER2- Breast Cancer

Adjuvant Palbociclib Plus Endocrine Therapy Does Not Improve Outcomes in Patients with Breast Cancer

Adjuvant Palbociclib Plus Endocrine Therapy Does Not Improve Outcomes in Patients with Breast Cancer

Pregnancy Does Not Worsen Outcomes in Triple-Negative Breast Cancer

Pregnancy Does Not Worsen Outcomes in Triple-Negative Breast Cancer

ASCO Updates Guidelines for Patients with HER2+ Breast Cancer and Brain Metastasis

ASCO Updates Guidelines for Patients with HER2+ Breast Cancer and Brain Metastasis

Lumpectomy, Mastectomy Result in Similar Outcomes in Younger Patients with Breast Cancer

Lumpectomy, Mastectomy Result in Similar Outcomes in Younger Patients with Breast Cancer

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Study Shows Tolerable Safety of Abemaciclib Plus Pembrolizumab in HER2-, Metastatic Breast Cancer

RNA TROJAN Promotes Triple-Negative Breast Cancer Progression

RNA TROJAN Promotes Triple-Negative Breast Cancer Progression

ASCO Updates Guidelines for Pembrolizumab Treatment in Patients with Early-Stage TNBC

ASCO Updates Guidelines for Pembrolizumab Treatment in Patients with Early-Stage TNBC

Oral Paclitaxel-Encequidar Superior to IV Paclitaxel in Metastatic Breast Cancer

Oral Paclitaxel-Encequidar Superior to IV Paclitaxel in Metastatic Breast Cancer

Olaparib Improves Survival in High Risk Early-Stage Breast Cancer

Olaparib Improves Survival in High Risk Early-Stage Breast Cancer

Atezolizumab Withdrawn from FDA Accelerated Approval for TNBC

Atezolizumab Withdrawn from FDA Accelerated Approval for TNBC

Neoadjuvant Opportunities in Early, High-Risk Breast Cancer

Neoadjuvant Opportunities in Early, High-Risk Breast Cancer

Overcoming Treatment Resistance in Breast Cancer

Overcoming Treatment Resistance in Breast Cancer

FDA Committee Delays Approval of Pembrolizumab for Early TNBC

FDA Committee Delays Approval of Pembrolizumab for Early TNBC

ASCO Issues Guidelines for Telemedicine in Oncology

ASCO Issues Guidelines for Telemedicine in Oncology

Sacituzumab Govitecan Safe and Effective in Patients 65 and Older with TNBC

Sacituzumab Govitecan Safe and Effective in Patients 65 and Older with TNBC

Nitric Oxide Synthase Inhibitor Plus Taxane Show Promise in Chemoresistant TNBC

Nitric Oxide Synthase Inhibitor Plus Taxane Show Promise in Chemoresistant TNBC

FDA Approves Sacituzumab Govitecan-hziy for Metastatic TNBC

FDA Approves Sacituzumab Govitecan-hziy for Metastatic TNBC

Results from BEATRICE and I–SPY2 Trials in TNBC and HR+/HER2- Breast Cancer

Results from BEATRICE and I–SPY2 Trials in TNBC and HR+/HER2- Breast Cancer

EU approves HER2+ Metastatic Breast Cancer Treatment

EU approves HER2+ Metastatic Breast Cancer Treatment

HER2CLIMB Study Shows Benefits of Triple Therapy for HER2+ Metastatic Breast Cancer with Brain Metastases

HER2CLIMB Study Shows Benefits of Triple Therapy for HER2+ Metastatic Breast Cancer with Brain Metastases

Advancing Breast Cancer Care With Gammapod Radiation

Advancing Breast Cancer Care With Gammapod Radiation

Studies Emphasizes Need for Universal Testing in Breast Cancer Treatment

Studies Emphasizes Need for Universal Testing in Breast Cancer Treatment

Trastuzumab Deruxtecan Lowers Risk of Progression in HER2+ Breast Cancer

Trastuzumab Deruxtecan Lowers Risk of Progression in HER2+ Breast Cancer

SABCS 2023 Annual Meeting

Less Frequent Mammography for Breast Cancer Survivors Has No Impact on Survival

Less Frequent Mammography for Breast Cancer Survivors Has No Impact on Survival

Fertility Preservation Safe for Patients Who Pause HR-positive Breast Cancer Endocrine Therapy to Conceive

Fertility Preservation Safe for Patients Who Pause HR-positive Breast Cancer Endocrine Therapy to Conceive

Patients with Breast Cancer That Converts from Lymph Node-Positive to -Negative Can Skip Adjuvant Irradiation

Patients with Breast Cancer That Converts from Lymph Node-Positive to -Negative Can Skip Adjuvant Irradiation

Tucatinib Plus Trastuzumab Emtansine Extend PFS in Late-Stage HER2-Positive Breast Cancer

Tucatinib Plus Trastuzumab Emtansine Extend PFS in Late-Stage HER2-Positive Breast Cancer

Younger Postmenopausal Patients May Skip Adjuvant Radiotherapy After Early Breast Cancer Surgery

Younger Postmenopausal Patients May Skip Adjuvant Radiotherapy After Early Breast Cancer Surgery

MD /Alert Exclusives

ASCO, SSO Publish Guidelines for Germline Mutation Testing in Breast Cancer

ASCO, SSO Publish Guidelines for Germline Mutation Testing in Breast Cancer

Less Frequent Mammography for Breast Cancer Survivors Has No Impact on Survival

Less Frequent Mammography for Breast Cancer Survivors Has No Impact on Survival

Fertility Preservation Safe for Patients Who Pause HR-positive Breast Cancer Endocrine Therapy to Conceive

Fertility Preservation Safe for Patients Who Pause HR-positive Breast Cancer Endocrine Therapy to Conceive

Patients with Breast Cancer That Converts from Lymph Node-Positive to -Negative Can Skip Adjuvant Irradiation

Patients with Breast Cancer That Converts from Lymph Node-Positive to -Negative Can Skip Adjuvant Irradiation

Tucatinib Plus Trastuzumab Emtansine Extend PFS in Late-Stage HER2-Positive Breast Cancer

Tucatinib Plus Trastuzumab Emtansine Extend PFS in Late-Stage HER2-Positive Breast Cancer

Younger Postmenopausal Patients May Skip Adjuvant Radiotherapy After Early Breast Cancer Surgery

Younger Postmenopausal Patients May Skip Adjuvant Radiotherapy After Early Breast Cancer Surgery

Sacituzumab Govitecan Improves OS in Endocrine-Resistant Metastatic Breast Cancer

Sacituzumab Govitecan Improves OS in Endocrine-Resistant Metastatic Breast Cancer

Pertuzumab, Trastuzumab Combination Effective in HER2+ Metastatic Breast Cancer

Pertuzumab, Trastuzumab Combination Effective in HER2+ Metastatic Breast Cancer

PET-CT Scanning Improves Detection of Metastases in Patients With Locally Advanced Breast Cancer

PET-CT Scanning Improves Detection of Metastases in Patients With Locally Advanced Breast Cancer

NCCN Clinical Practice Guidelines Recommend FES PET Imaging for ER+ Breast Cancer

NCCN Clinical Practice Guidelines Recommend FES PET Imaging for ER+ Breast Cancer

Camizestrant Improves PFS in Patients with HR+/HER2– Breast Cancer

Camizestrant Improves PFS in Patients with HR+/HER2– Breast Cancer

Some Patients with Invasive Breast Cancer Can Skip Surgery

Some Patients with Invasive Breast Cancer Can Skip Surgery

No OS Benefit with Margetuximab Over Trastuzumab in Previously Treated HER2+ Breast Cancer

No OS Benefit with Margetuximab Over Trastuzumab in Previously Treated HER2+ Breast Cancer

Plasmid DNA Vaccine Shows Promise in Patients with Advanced-Stage ERBB2+ Breast Cancer

Plasmid DNA Vaccine Shows Promise in Patients with Advanced-Stage ERBB2+ Breast Cancer

Trastuzumab Deruxtecan Significantly Improves OS, PFS in Patients with MBC

Trastuzumab Deruxtecan Significantly Improves OS, PFS in Patients with MBC

Ribociclib, Endocrine Therapy Combination Improves PFS in Aggressive Breast Cancer

Ribociclib, Endocrine Therapy Combination Improves PFS in Aggressive Breast Cancer

Inflammatory Markers May Predict Frailty After Chemotherapy

Inflammatory Markers May Predict Frailty After Chemotherapy

Oral Paclitaxel-Encequidar Superior to IV Paclitaxel in Metastatic Breast Cancer

Oral Paclitaxel-Encequidar Superior to IV Paclitaxel in Metastatic Breast Cancer

FDA Gives Priority Review for HR+, HER2– Advanced Breast Cancer Therapy

FDA Gives Priority Review for HR+, HER2– Advanced Breast Cancer Therapy

FDA Approves Companion Diagnostic for Patients with Breast Cancer, Low HER2 Expression

FDA Approves Companion Diagnostic for Patients with Breast Cancer, Low HER2 Expression

New Test May Detect Multiple Cancers, Tumor Points of Origin

New Test May Detect Multiple Cancers, Tumor Points of Origin

20-Year Benefit from Endocrine Therapy in Premenopausal Patients with Breast Cancer

20-Year Benefit from Endocrine Therapy in Premenopausal Patients with Breast Cancer

Atezolizumab Does Not Improve Pathologic Complete Response Rates in HER2+ Early Breast Cancer

Atezolizumab Does Not Improve Pathologic Complete Response Rates in HER2+ Early Breast Cancer

The Metastatic Spread of Breast Cancer Accelerates During Sleep

The Metastatic Spread of Breast Cancer Accelerates During Sleep

NCCN Report Advises on Use of Pembrolizumab in Triple-Negative Breast Cancer

NCCN Report Advises on Use of Pembrolizumab in Triple-Negative Breast Cancer

Pertuzumab-Based Regimen Continues to Reduce Recurrence in Patients with Early Breast Cancer

Pertuzumab-Based Regimen Continues to Reduce Recurrence in Patients with Early Breast Cancer

FDA Approves Trastuzumab Deruxtecan for HER2-Low Breast Cancer

FDA Approves Trastuzumab Deruxtecan for HER2-Low Breast Cancer

ICI-Related Major Adverse Cardiac Events Rare, but Cause Significant Morbidity

ICI-Related Major Adverse Cardiac Events Rare, but Cause Significant Morbidity

Olaparib Recommended for European Approval for Patients with High-Risk Early Breast Cancer

Olaparib Recommended for European Approval for Patients with High-Risk Early Breast Cancer

European Commission Approves Trastuzumab Deruxtecan for Second-Line HER2+ Breast Cancer

European Commission Approves Trastuzumab Deruxtecan for Second-Line HER2+ Breast Cancer

ASCO Updates Guidelines for Patients with HER2+ Breast Cancer and Brain Metastasis

ASCO Updates Guidelines for Patients with HER2+ Breast Cancer and Brain Metastasis

Neoadjuvant Amcenestrant Shows Robust Response in Postmenopausal ER+/HER2- Breast Cancer

Neoadjuvant Amcenestrant Shows Robust Response in Postmenopausal ER+/HER2- Breast Cancer

ASCO Updates Guidelines for Systemic Therapy in Advanced HER2+ Breast Cancer

ASCO Updates Guidelines for Systemic Therapy in Advanced HER2+ Breast Cancer

Treatment Combination Shows Promise in HR+, HER2–, HER2-mutant Metastatic Breast Cancer

Treatment Combination Shows Promise in HR+, HER2–, HER2-mutant Metastatic Breast Cancer

Zanidatamab-Docetaxel Effective as First-Line Therapy in Advanced HER2+ Breast Cancer

Zanidatamab-Docetaxel Effective as First-Line Therapy in Advanced HER2+ Breast Cancer

Perioperative Combination Therapy Identifies Responders in Early HER2+ Breast Cancer

Perioperative Combination Therapy Identifies Responders in Early HER2+ Breast Cancer

FDA Approves Biosimilar Treatment for Cancer-Related Neutropenia

FDA Approves Biosimilar Treatment for Cancer-Related Neutropenia

Metformin Does Not Improve Disease-Free Survival in Early-Stage Breast Cancer Patients

Metformin Does Not Improve Disease-Free Survival in Early-Stage Breast Cancer Patients

Sacituzumab Govitecan Safe and Effective in Patients 65 and Older with TNBC

Sacituzumab Govitecan Safe and Effective in Patients 65 and Older with TNBC

FDA Approves AI Algorithms for Breast Cancer Detection

FDA Approves AI Algorithms for Breast Cancer Detection

Palbociclib Combination Fails to Extend Overall Survival for Advanced Breast Cancer

Palbociclib Combination Fails to Extend Overall Survival for Advanced Breast Cancer

Protein Coding Gene Enhances Cisplatin Resistance in Triple-Negative Breast Cancer

Protein Coding Gene Enhances Cisplatin Resistance in Triple-Negative Breast Cancer

Trastuzumab Deruxtecan Highly Effective in Patients with HER2-Low Metastatic Breast Cancer

Trastuzumab Deruxtecan Highly Effective in Patients with HER2-Low Metastatic Breast Cancer

Clinical Trials Need Better Representation Among Black Patients

Clinical Trials Need Better Representation Among Black Patients

FDA Grants Bria-IMT Immunotherapy for Metastatic Breast Cancer Fast Track Status

FDA Grants Bria-IMT Immunotherapy for Metastatic Breast Cancer Fast Track Status

Adjuvant Palbociclib Plus Endocrine Therapy Does Not Improve Outcomes in Patients with Breast Cancer

Adjuvant Palbociclib Plus Endocrine Therapy Does Not Improve Outcomes in Patients with Breast Cancer

Lumpectomy, Mastectomy Result in Similar Outcomes in Younger Patients with Breast Cancer

Lumpectomy, Mastectomy Result in Similar Outcomes in Younger Patients with Breast Cancer

ASCO Updates Guidelines for Pembrolizumab Treatment in Patients with Early-Stage TNBC

ASCO Updates Guidelines for Pembrolizumab Treatment in Patients with Early-Stage TNBC

Results from BEATRICE and I–SPY2 Trials in TNBC and HR+/HER2- Breast Cancer

Results from BEATRICE and I–SPY2 Trials in TNBC and HR+/HER2- Breast Cancer

No Benefit with Early Local Therapy In De Novo Metastatic Breast Cancer

No Benefit with Early Local Therapy In De Novo Metastatic Breast Cancer

Ribociclib Plus Letrozole Shows Overall Survival Benefit in HR+/HER2- Advanced Breast Cancer

Ribociclib Plus Letrozole Shows Overall Survival Benefit in HR+/HER2- Advanced Breast Cancer

Trastuzumab Deruxtecan Lowers Risk of Progression in HER2+ Breast Cancer

Trastuzumab Deruxtecan Lowers Risk of Progression in HER2+ Breast Cancer

Trastuzumab Deruxtecan Lowers Risk of Progression in HER2+ Breast Cancer

Trastuzumab Deruxtecan Lowers Risk of Progression in HER2+ Breast Cancer

Breast Cancer Clinical Trial Fails to Meet Primary Endpoint

Breast Cancer Clinical Trial Fails to Meet Primary Endpoint

Olaparib Improves Survival in High Risk Early-Stage Breast Cancer

Olaparib Improves Survival in High Risk Early-Stage Breast Cancer

FDA Grants Fast Track Designation to Novel Treatment in Breast Cancer

FDA Grants Fast Track Designation to Novel Treatment in Breast Cancer

Researchers Identify Target of Metastasis in Triple-Negative Breast Cancer

Researchers Identify Target of Metastasis in Triple-Negative Breast Cancer

FDA Approval in BRCA Mutated HER2-negative High-Risk Early Breast Cancer

FDA Approval in BRCA Mutated HER2-negative High-Risk Early Breast Cancer

Treatment Combination Reduces Recurrence in Early-Stage Breast Cancer

Treatment Combination Reduces Recurrence in Early-Stage Breast Cancer

ASCO Issues Guidelines for Telemedicine in Oncology

ASCO Issues Guidelines for Telemedicine in Oncology

FDA Approves Diagnostic to Identify Microsatellite Instability-High Solid Tumors

FDA Approves Diagnostic to Identify Microsatellite Instability-High Solid Tumors

Pregnancy Does Not Worsen Outcomes in Triple-Negative Breast Cancer

Pregnancy Does Not Worsen Outcomes in Triple-Negative Breast Cancer

Metastatic Breast Cancer Therapy Gains Fast Track Designation

Metastatic Breast Cancer Therapy Gains Fast Track Designation

Nitric Oxide Synthase Inhibitor Plus Taxane Show Promise in Chemoresistant TNBC

Nitric Oxide Synthase Inhibitor Plus Taxane Show Promise in Chemoresistant TNBC

FDA Accepts Biologics License Application for New Metastatic HER2+ Breast Cancer Treatment

FDA Accepts Biologics License Application for New Metastatic HER2+ Breast Cancer Treatment

FDA Grants Fast Track Designation in HR+/HER2- Metastatic Breast Cancer

FDA Grants Fast Track Designation in HR+/HER2- Metastatic Breast Cancer

New Vaccine to Prevent Breast Cancer in Early Clinical Trials

New Vaccine to Prevent Breast Cancer in Early Clinical Trials

Therapy Targeting Inducible Nitric Oxide Signaling Shows Promise in TNBC

Therapy Targeting Inducible Nitric Oxide Signaling Shows Promise in TNBC

Trastuzumab Deruxtecan Improves Survival in HER2-Positive Breast Cancer

Trastuzumab Deruxtecan Improves Survival in HER2-Positive Breast Cancer

FDA Approves Combo of Abemaciclib, Endocrine Therapy for Early Breast Cancer

FDA Approves Combo of Abemaciclib, Endocrine Therapy for Early Breast Cancer

Atezolizumab Withdrawn from FDA Accelerated Approval for TNBC

Atezolizumab Withdrawn from FDA Accelerated Approval for TNBC

Celecoxib Shows No Benefit for Patients with Early Breast Cancer

Celecoxib Shows No Benefit for Patients with Early Breast Cancer

Research Shows Benefits of Pembrolizumab as Single Agent TNBC Treatment

Research Shows Benefits of Pembrolizumab as Single Agent TNBC Treatment

Chemotherapy Plus Treatment Combination for ERBB2-positive MBC Inferior in Clinical Practice

Chemotherapy Plus Treatment Combination for ERBB2-positive MBC Inferior in Clinical Practice

ASCO Guideline on Adjuvant Olaparib in Patients with HER2-negative Breast Cancer

ASCO Guideline on Adjuvant Olaparib in Patients with HER2-negative Breast Cancer

Durvalumab Provokes Robust Long-Term Outcomes in Patients with TNBC

Durvalumab Provokes Robust Long-Term Outcomes in Patients with TNBC

Endocrine Therapy Noninferior to Chemotherapy as First-Line Treatment for Patients with MBC

Endocrine Therapy Noninferior to Chemotherapy as First-Line Treatment for Patients with MBC

Adjuvant Olaparib Significantly Improves Invasive DFS in Patients with High-Risk EBC, BRCA Mutations

Adjuvant Olaparib Significantly Improves Invasive DFS in Patients with High-Risk EBC, BRCA Mutations

FDA Approves Sacituzumab Govitecan-hziy for Metastatic TNBC

FDA Approves Sacituzumab Govitecan-hziy for Metastatic TNBC

European Regulators Validate TNBC Biologic Treatment Application

European Regulators Validate TNBC Biologic Treatment Application

FDA Rejects Breast Cancer Therapy Due to Safety Concerns

FDA Rejects Breast Cancer Therapy Due to Safety Concerns

Large Epidemiology Study Updates Breast Cancer Risk for Women Lacking Family History

Large Epidemiology Study Updates Breast Cancer Risk for Women Lacking Family History

FDA Committee Delays Approval of Pembrolizumab for Early TNBC

FDA Committee Delays Approval of Pembrolizumab for Early TNBC

1:25 MD /Alert Exclusive

FDA Clears First Clinical Trial for Breast Cancer Vaccine

Helping Breast Cancer Oncologists Work ‘In the Trenches’

Helping Breast Cancer Oncologists Work ‘In the Trenches’

New ASCO, ASTRO, SSO Joint Clinical Guidelines for Hereditary Breast Cancer

New ASCO, ASTRO, SSO Joint Clinical Guidelines for Hereditary Breast Cancer

EU approves HER2+ Metastatic Breast Cancer Treatment

EU approves HER2+ Metastatic Breast Cancer Treatment

Studies Emphasizes Need for Universal Testing in Breast Cancer Treatment

Studies Emphasizes Need for Universal Testing in Breast Cancer Treatment

Impassion031 Outcomes Show Importance of Looking Beyond Initial Trial Data

Impassion031 Outcomes Show Importance of Looking Beyond Initial Trial Data

Combination Therapy Fails to Meet Primary Endpoints in HR+ HER2- Breast Cancer Treatment

Combination Therapy Fails to Meet Primary Endpoints in HR+ HER2- Breast Cancer Treatment

Mindfulness Shows Benefits for Young Breast Cancer

Mindfulness Shows Benefits for Young Breast Cancer

Time to Treatment Completion Associated with Poor Breast Cancer Survival

Time to Treatment Completion Associated with Poor Breast Cancer Survival

Neratinib + Capecitabine Improves QoL for HER2+ Metastatic Breast Cancer

Neratinib + Capecitabine Improves QoL for HER2+ Metastatic Breast Cancer

Study Shows Breastfeeding Can be Safe for Breast Cancer Survivors

Study Shows Breastfeeding Can be Safe for Breast Cancer Survivors

Abemaciclib Represents ‘New Standard of Care’ for Patients With High-Risk Early Breast Cancer

Abemaciclib Represents ‘New Standard of Care’ for Patients With High-Risk Early Breast Cancer

Sacituzumab Govitecan Extends Survival in Metastatic Triple-Negative Breast Cancer

Sacituzumab Govitecan Extends Survival in Metastatic Triple-Negative Breast Cancer

FDA Issues Warning Alert for Atezolizumab/Paclitaxel Combo in TNBC

FDA Issues Warning Alert for Atezolizumab/Paclitaxel Combo in TNBC

Nobel Prize Winner Links Cancer Immunotherapy to Programmed Cell Death Gene

Nobel Prize Winner Links Cancer Immunotherapy to Programmed Cell Death Gene

Neratinib and Capecitabine Improves PFS in HER2+ Metastatic Breast Cancer

Neratinib and Capecitabine Improves PFS in HER2+ Metastatic Breast Cancer

MINDACT Study Shows Continued Success in Determining Chemotherapy Usage

MINDACT Study Shows Continued Success in Determining Chemotherapy Usage

Pembrolizumab + Chemotherapy Beneficial in Triple-Negative Breast Cancer

Pembrolizumab + Chemotherapy Beneficial in Triple-Negative Breast Cancer

Advanced ER+ HER2+ Breast Cancer Combo Therapy Fails to Improve Outcomes

Advanced ER+ HER2+ Breast Cancer Combo Therapy Fails to Improve Outcomes

HER2CLIMB Study Shows Benefits of Triple Therapy for HER2+ Metastatic Breast Cancer with Brain Metastases

HER2CLIMB Study Shows Benefits of Triple Therapy for HER2+ Metastatic Breast Cancer with Brain Metastases

Featured Breast Cancer Videos

Neoadjuvant Opportunities in Early, High-Risk Breast Cancer

Neoadjuvant Opportunities in Early, High-Risk Breast Cancer

Integrating Tailored Therapy in Early, High-Risk Breast Cancer

Integrating Tailored Therapy in Early, High-Risk Breast Cancer

Providing Equitable Care in Early Breast Cancer

Providing Equitable Care in Early Breast Cancer

Going the Distance With Metastatic Breast Cancer: 'Personal Best'

Going the Distance With Metastatic Breast Cancer: "Personal Best"

Metastatic Breast Cancer: 'The Journey Begins'

Metastatic Breast Cancer: "The Journey Begins"

Breaking Research

Personalized Assay Surpasses Limits for Detecting Tumor DNA in Breast Cancer Patients

Personalized Assay Surpasses Limits for Detecting Tumor DNA in Breast Cancer Patients

Overcoming Treatment Resistance in Breast Cancer

Overcoming Treatment Resistance in Breast Cancer

Oncologist Explains How Gammapod Works for Breast Cancer

Oncologist Explains How Gammapod Works for Breast Cancer

Advancing Breast Cancer Care With Gammapod Radiation

Advancing Breast Cancer Care With Gammapod Radiation

RNA TROJAN Promotes Triple-Negative Breast Cancer Progression

RNA TROJAN Promotes Triple-Negative Breast Cancer Progression

Preventing Breast Cancer in Women Carrying BRCA1 Gene

Preventing Breast Cancer in Women Carrying BRCA1 Gene

ASCO 2023 Annual Meeting

Donepezil Does Not Improve Cancer-Related Cognitive Impairment in Breast Cancer Survivors

Donepezil Does Not Improve Cancer-Related Cognitive Impairment in Breast Cancer Survivors

Breast Cancer Index Risk Scores a Prognostic Indicator of Overall, Late Distant Recurrence

Breast Cancer Index Risk Scores a Prognostic Indicator of Overall, Late Distant Recurrence

HER3-DXd Promotes Clinical Activity in MBC at Varying HER3 Expression Levels

HER3-DXd Promotes Clinical Activity in MBC at Varying HER3 Expression Levels

Capecitabine Has Less Toxicity, Similar Survival in Metastatic Breast Cancer with Fixed Dose

Capecitabine Has Less Toxicity, Similar Survival in Metastatic Breast Cancer with Fixed Dose

Greater Weight Loss Among Women with Breast Cancer After Phone-Based Coaching

Greater Weight Loss Among Women with Breast Cancer After Phone-Based Coaching

Curated For You

Genomic Profiling Improves Metastatic Breast Cancer Research

Genomic Profiling Improves Metastatic Breast Cancer Research

New Uses for Existing Therapies in Breast Cancer Research

New Uses for Existing Therapies in Breast Cancer Research

Various Breast Cancer Research Challenges in Recurrence, Triple Negative BC

Various Breast Cancer Research Challenges in Recurrence, Triple Negative BC

Understanding Recent Breast Cancer Vaccine Breakthroughs

Understanding Recent Breast Cancer Vaccine Breakthroughs

Study of Immunotherapy Combinations for Patients with Metastatic Breast Cancer

Study of Immunotherapy Combinations for Patients with Metastatic Breast Cancer

Why Dual Light Therapy Hits Triple Negative Breast Cancer Harder

Why Dual Light Therapy Hits Triple Negative Breast Cancer Harder

Improving Outcomes for Early Onset Breast Cancer

Improving Outcomes for Early Onset Breast Cancer

SABCS 2022 Annual Meeting

Capivasertib, Fulvestrant Improves PFS in Patients with HR+/HER2– Breast Cancer

Capivasertib, Fulvestrant Improves PFS in Patients with HR+/HER2– Breast Cancer

Camizestrant Improves PFS in Patients with HR+/HER2– Breast Cancer

Camizestrant Improves PFS in Patients with HR+/HER2– Breast Cancer

Trastuzumab Deruxtecan Significantly Improves OS, PFS in Patients with MBC

Trastuzumab Deruxtecan Significantly Improves OS, PFS in Patients with MBC

Ribociclib, Endocrine Therapy Combination Improves PFS in Aggressive Breast Cancer

Ribociclib, Endocrine Therapy Combination Improves PFS in Aggressive Breast Cancer

ASCO 2022 Annual Meeting

FDA Approves Trastuzumab Deruxtecan for HER2-Low Breast Cancer

FDA Approves Trastuzumab Deruxtecan for HER2-Low Breast Cancer

European Commission Approves Trastuzumab Deruxtecan for Second-Line HER2+ Breast Cancer

European Commission Approves Trastuzumab Deruxtecan for Second-Line HER2+ Breast Cancer

Treatment Combination Shows Promise in HR+, HER2–, HER2-mutant Metastatic Breast Cancer

Treatment Combination Shows Promise in HR+, HER2–, HER2-mutant Metastatic Breast Cancer

Zanidatamab-Docetaxel Effective as First-Line Therapy in Advanced HER2+ Breast Cancer

Zanidatamab-Docetaxel Effective as First-Line Therapy in Advanced HER2+ Breast Cancer

Sacituzumab Govitecan Safe and Effective in Patients 65 and Older with TNBC

Sacituzumab Govitecan Safe and Effective in Patients 65 and Older with TNBC

Palbociclib Combination Fails to Extend Overall Survival for Advanced Breast Cancer

Palbociclib Combination Fails to Extend Overall Survival for Advanced Breast Cancer

Trastuzumab Deruxtecan Highly Effective in Patients with HER2-Low Metastatic Breast Cancer

Trastuzumab Deruxtecan Highly Effective in Patients with HER2-Low Metastatic Breast Cancer

Clinical Trials Need Better Representation Among Black Patients

Clinical Trials Need Better Representation Among Black Patients

SABCS 2020 Annual Meeting

FDA Committee Delays Approval of Pembrolizumab for Early TNBC

FDA Committee Delays Approval of Pembrolizumab for Early TNBC

1:25 MD /Alert Exclusive

FDA Clears First Clinical Trial for Breast Cancer Vaccine

Helping Breast Cancer Oncologists Work ‘In the Trenches’

Helping Breast Cancer Oncologists Work ‘In the Trenches’

EU approves HER2+ Metastatic Breast Cancer Treatment

EU approves HER2+ Metastatic Breast Cancer Treatment

Studies Emphasizes Need for Universal Testing in Breast Cancer Treatment

Studies Emphasizes Need for Universal Testing in Breast Cancer Treatment

Impassion031 Outcomes Show Importance of Looking Beyond Initial Trial Data

Impassion031 Outcomes Show Importance of Looking Beyond Initial Trial Data

Combination Therapy Fails to Meet Primary Endpoints in HR+ HER2- Breast Cancer Treatment

Combination Therapy Fails to Meet Primary Endpoints in HR+ HER2- Breast Cancer Treatment

Mindfulness Shows Benefits for Young Breast Cancer

Mindfulness Shows Benefits for Young Breast Cancer

Time to Treatment Completion Associated with Poor Breast Cancer Survival

Time to Treatment Completion Associated with Poor Breast Cancer Survival

Neratinib + Capecitabine Improves QoL for HER2+ Metastatic Breast Cancer

Neratinib + Capecitabine Improves QoL for HER2+ Metastatic Breast Cancer

ASCO 2020 Annual Meeting

MINDACT Study Shows Continued Success in Determining Chemotherapy Usage

MINDACT Study Shows Continued Success in Determining Chemotherapy Usage

Pembrolizumab + Chemotherapy Beneficial in Triple-Negative Breast Cancer

Pembrolizumab + Chemotherapy Beneficial in Triple-Negative Breast Cancer

Advanced ER+ HER2+ Breast Cancer Combo Therapy Fails to Improve Outcomes

Advanced ER+ HER2+ Breast Cancer Combo Therapy Fails to Improve Outcomes

HER2CLIMB Study Shows Benefits of Triple Therapy for HER2+ Metastatic Breast Cancer with Brain Metastases

HER2CLIMB Study Shows Benefits of Triple Therapy for HER2+ Metastatic Breast Cancer with Brain Metastases

Study Shows Tolerable Safety of Abemaciclib Plus Pembrolizumab in HER2-, Metastatic Breast Cancer

Study Shows Tolerable Safety of Abemaciclib Plus Pembrolizumab in HER2-, Metastatic Breast Cancer

Combining Eribulin and Pembrolizumab in Metastatic Triple-Negative Breast Cancer

Combining Eribulin and Pembrolizumab in Metastatic Triple-Negative Breast Cancer