SABCS: Phase 3 Studies Set to Reshape Breast Cancer Care

Virginia Kaklamani, MD, DSc, professor of medicine at The University of Texas at San Antonio, leader of the breast cancer program at the Mays Cancer Center, and co-director for the San Antonio Breast Cancer Symposium (SABCS) 2025, spoke with MD /alert about the new research expected at the symposium this year. SABCS will take place from December 9-12 in San Antonio, Texas.

Disclosures: Kaklamani declared relevant financial disclosures with Gilead, AstraZeneca, Daichii, Menarini, and Genentech.

Any views expressed above are the author's own and do not necessarily reflect the views of MD /alert. This transcript was digitally generated and edited for clarity.

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Real-World Analysis Suggests Lower Brain Metastasis Risk With T-DXd vs TTC in Patients With HER2+ Metastatic Breast Cancer

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Tucatinib Extends PFS Across Key Subgroups in Patients With HER2+ Metastatic Breast Cancer

Sacituzumab Govitecan Improves PFS2 in Patients With Previously Untreated TNBC

Sacituzumab Govitecan Improves PFS2 in Patients With Previously Untreated TNBC

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Giredestrant Highly Effective in Early Breast Cancer, Regardless of Menopausal Status

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Weight-Loss Intervention Improves Physical Functioning, Quality of Life in Breast Cancer

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DESTINY-Breast11 Safety Analysis: Trastuzumab Deruxtecan Demonstrates Favorable Adverse Event Outcomes

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AI Tool Improves Accuracy, Reduces Equivocal Results in HER2 Breast Cancer Scoring

Extended Adjuvant Endocrine Therapy Improves Outcomes in BRCA Carriers

Extended Adjuvant Endocrine Therapy Improves Outcomes in BRCA Carriers

Imlunestrant, Abemaciclib Improve OS in Patients With Advanced Breast Cancer

Imlunestrant, Abemaciclib Improve OS in Patients With Advanced Breast Cancer

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Certain Adverse Events Predict Complete Response in Early Breast Cancer

SABCS: Phase 3 Studies Set to Reshape Breast Cancer Care

SABCS: Phase 3 Studies Set to Reshape Breast Cancer Care

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Know Before You Go: SABCS 2025

MD /Alert Exclusives

Researchers Address Potential Cardiotoxicity Concerns of Aromatase Inhibitors in Early Breast Cancer

Researchers Address Potential Cardiotoxicity Concerns of Aromatase Inhibitors in Early Breast Cancer

FDA Approves Tucatinib as Maintenance Therapy for HER2-Positive Breast Cancer

FDA Approves Tucatinib as Maintenance Therapy for HER2-Positive Breast Cancer

FDA Approves Palbociclib With Trastuzumab for HR-Positive, HER2-Positive MBC

FDA Approves Palbociclib With Trastuzumab for HR-Positive, HER2-Positive MBC

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Rilvegostomig Plus Trastuzumab Deruxtecan Allows Certain Patients to Skip Breast Cancer Chemotherapy

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Real-World Analysis Suggests Lower Brain Metastasis Risk With T-DXd vs TTC in Patients With HER2+ Metastatic Breast Cancer

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Sacituzumab Govitecan Improves PFS2 in Patients With Previously Untreated TNBC

Weight-Loss Intervention Improves Physical Functioning, Quality of Life in Breast Cancer

Weight-Loss Intervention Improves Physical Functioning, Quality of Life in Breast Cancer

Bireociclib, Fulvestrant Improve PFS After Endocrine Therapy in Advanced Breast Cancer

Bireociclib, Fulvestrant Improve PFS After Endocrine Therapy in Advanced Breast Cancer

Exemestane Less Effective Than Other Aromatase Inhibitors for Postmenopausal BC Patients

Exemestane Less Effective Than Other Aromatase Inhibitors for Postmenopausal BC Patients

AI Tool Improves Accuracy, Reduces Equivocal Results in HER2 Breast Cancer Scoring

AI Tool Improves Accuracy, Reduces Equivocal Results in HER2 Breast Cancer Scoring

Imlunestrant, Abemaciclib Improve OS in Patients With Advanced Breast Cancer

Imlunestrant, Abemaciclib Improve OS in Patients With Advanced Breast Cancer

Parity and Breastfeeding Confer T-Cell Protection Against Breast Cancer

Parity and Breastfeeding Confer T-Cell Protection Against Breast Cancer

Adjuvant Chemotherapy Offers No Survival Benefit for Older Patients With Breast Cancer

Adjuvant Chemotherapy Offers No Survival Benefit for Older Patients With Breast Cancer

Ribociclib, Trastuzumab, Letrozole Combination Extends Survival in HR+/ HER2+ Advanced Breast Cancer

Ribociclib, Trastuzumab, Letrozole Combination Extends Survival in HR+/ HER2+ Advanced Breast Cancer

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Model Predicts Future Risk of Breast Cancer Following ER+/HER2- Breast Cancer

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Sacituzumab Govitecan, Pembrolizumab Effective for Early Triple-Negative Breast Cancer

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Black, Latinx, and Asian Women Less Likely to Receive Biomarker Testing Following Metastatic Breast Cancer Diagnosis

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Elacestrant May Offer ‘Endocrine Therapy Backbone’ in ER+/ HER2- Breast Cancer

Combination Inavolisib, Palbociclib, Fulvestrant Boosts Survival for PIK3CA-Mutated HR+, HER2-, Endocrine-Resistant Advanced Breast Cancer

Combination Inavolisib, Palbociclib, Fulvestrant Boosts Survival for PIK3CA-Mutated HR+, HER2-, Endocrine-Resistant Advanced Breast Cancer

Artificial Intelligence Training Platform Aids in Better HER2 Immunohistochemistry Scoring

Artificial Intelligence Training Platform Aids in Better HER2 Immunohistochemistry Scoring

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Certain Patients with Invasive Breast Cancer Can Achieve Long-Term Disease Control Without Surgery

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FDA Approves Trastuzumab Deruxtecan in Earlier Line of HER2-low, Ultralow Breast Cancer

Reducing the Digital Burden in Cancer Care Delivery, Knowledge

Reducing the Digital Burden in Cancer Care Delivery, Knowledge

Sacituzumab Govitecan Improves Outcomes for Pretreated Triple-Negative Breast Cancer

Sacituzumab Govitecan Improves Outcomes for Pretreated Triple-Negative Breast Cancer

ASCO, SSO Publish Guidelines for Germline Mutation Testing in Breast Cancer

ASCO, SSO Publish Guidelines for Germline Mutation Testing in Breast Cancer

Less Frequent Mammography for Breast Cancer Survivors Has No Impact on Survival

Less Frequent Mammography for Breast Cancer Survivors Has No Impact on Survival

Fertility Preservation Safe for Patients Who Pause HR-positive Breast Cancer Endocrine Therapy to Conceive

Fertility Preservation Safe for Patients Who Pause HR-positive Breast Cancer Endocrine Therapy to Conceive

Patients with Breast Cancer That Converts from Lymph Node-Positive to -Negative Can Skip Adjuvant Irradiation

Patients with Breast Cancer That Converts from Lymph Node-Positive to -Negative Can Skip Adjuvant Irradiation

Tucatinib Plus Trastuzumab Emtansine Extend PFS in Late-Stage HER2-Positive Breast Cancer

Tucatinib Plus Trastuzumab Emtansine Extend PFS in Late-Stage HER2-Positive Breast Cancer

Younger Postmenopausal Patients May Skip Adjuvant Radiotherapy After Early Breast Cancer Surgery

Younger Postmenopausal Patients May Skip Adjuvant Radiotherapy After Early Breast Cancer Surgery

Sacituzumab Govitecan Improves OS in Endocrine-Resistant Metastatic Breast Cancer

Sacituzumab Govitecan Improves OS in Endocrine-Resistant Metastatic Breast Cancer

Pertuzumab, Trastuzumab Combination Effective in HER2+ Metastatic Breast Cancer

Pertuzumab, Trastuzumab Combination Effective in HER2+ Metastatic Breast Cancer

PET-CT Scanning Improves Detection of Metastases in Patients With Locally Advanced Breast Cancer

PET-CT Scanning Improves Detection of Metastases in Patients With Locally Advanced Breast Cancer

NCCN Clinical Practice Guidelines Recommend FES PET Imaging for ER+ Breast Cancer

NCCN Clinical Practice Guidelines Recommend FES PET Imaging for ER+ Breast Cancer

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Neoadjuvant Opportunities in Early, High-Risk Breast Cancer

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Sacituzumab Govitecan, Pembrolizumab Effective for Early Triple-Negative Breast Cancer

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Elacestrant May Offer ‘Endocrine Therapy Backbone’ in ER+/ HER2- Breast Cancer

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Artificial Intelligence Training Platform Aids in Better HER2 Immunohistochemistry Scoring

Combination Inavolisib, Palbociclib, Fulvestrant Boosts Survival for PIK3CA-Mutated HR+, HER2-, Endocrine-Resistant Advanced Breast Cancer

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Sacituzumab Deruxtecan Improves Quality of Life in Patients with MBC

Circulating Tumor DNA May Independently Predict Survival Outcomes in MBC

Circulating Tumor DNA May Independently Predict Survival Outcomes in MBC

Trastuzumab Deruxtecan Improves Outcomes for Patients with Progression After Endocrine Therapy

Trastuzumab Deruxtecan Improves Outcomes for Patients with Progression After Endocrine Therapy

Certain Common Medications May Reduce Breast Cancer Risk

Certain Common Medications May Reduce Breast Cancer Risk

Adjuvant Endocrine Therapy Associated with Poor QoL in Older Patients with Early Breast Cancer

Adjuvant Endocrine Therapy Associated with Poor QoL in Older Patients with Early Breast Cancer

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Reasons to Attend SABCS 2024 and How to Make the Most of It

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Looking Ahead to SABCS with Program Director Kate Lathrop, MD

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Certain Lymphocytes Indicate Treatment Responsive in Early HER2+ Breast Cancer

Country of Origin Impacts Breast Cancer Outcomes Among Hispanic Patients in US

Country of Origin Impacts Breast Cancer Outcomes Among Hispanic Patients in US

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Intensive Chemotherapy Regimen Boosts Survival in TNBC Following Multigene Signature

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Highest Risk Luminal B-Type Tumors Have Poor Recurrence-Free Interval Rate

Hormone Receptor Positive Status Does Not Impact Prognosis in BRCA-Associated Early Breast Cancer

Hormone Receptor Positive Status Does Not Impact Prognosis in BRCA-Associated Early Breast Cancer

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Donepezil Does Not Improve Cancer-Related Cognitive Impairment in Breast Cancer Survivors

Donepezil Does Not Improve Cancer-Related Cognitive Impairment in Breast Cancer Survivors

Breast Cancer Index Risk Scores a Prognostic Indicator of Overall, Late Distant Recurrence

Breast Cancer Index Risk Scores a Prognostic Indicator of Overall, Late Distant Recurrence

HER3-DXd Promotes Clinical Activity in MBC at Varying HER3 Expression Levels

HER3-DXd Promotes Clinical Activity in MBC at Varying HER3 Expression Levels

Capecitabine Has Less Toxicity, Similar Survival in Metastatic Breast Cancer with Fixed Dose

Capecitabine Has Less Toxicity, Similar Survival in Metastatic Breast Cancer with Fixed Dose

Greater Weight Loss Among Women with Breast Cancer After Phone-Based Coaching

Greater Weight Loss Among Women with Breast Cancer After Phone-Based Coaching

SABCS 2023 Annual Meeting

Less Frequent Mammography for Breast Cancer Survivors Has No Impact on Survival

Less Frequent Mammography for Breast Cancer Survivors Has No Impact on Survival

Fertility Preservation Safe for Patients Who Pause HR-positive Breast Cancer Endocrine Therapy to Conceive

Fertility Preservation Safe for Patients Who Pause HR-positive Breast Cancer Endocrine Therapy to Conceive

Patients with Breast Cancer That Converts from Lymph Node-Positive to -Negative Can Skip Adjuvant Irradiation

Patients with Breast Cancer That Converts from Lymph Node-Positive to -Negative Can Skip Adjuvant Irradiation

Tucatinib Plus Trastuzumab Emtansine Extend PFS in Late-Stage HER2-Positive Breast Cancer

Tucatinib Plus Trastuzumab Emtansine Extend PFS in Late-Stage HER2-Positive Breast Cancer

Younger Postmenopausal Patients May Skip Adjuvant Radiotherapy After Early Breast Cancer Surgery

Younger Postmenopausal Patients May Skip Adjuvant Radiotherapy After Early Breast Cancer Surgery