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Novel Anti-PD-1 Inhibitor Improves NSCLC PFS in Combo With Chemo

Two New Targets Discovered for NSCLC Treatments

The majority of lung cancers are non-small-cell lung carcinomas (NSCLC). LKB1 is a commonly mutated gene that suppresses tumors and passes cellular signals in a chain reaction between 14 different enzymes.

Researchers from the Salk Institute studied which enzyme was responsible for tumor suppression, using CRISPR to inactivate each enzyme and noted the tumor growth.

The enzyme SIK1 had the strongest effect on tumor suppression and SIK3 also had an affect. When these enzymes were inactive, tumor growth increased as well as inflammation.

Developing therapies to restore function to SIK1 and SIK3 could lead to better outcomes for patients with non-small-cell lumg carcinomas, according to researchers from Salk Institute.

Video Content: Salk Institute
Video Source: EurekAlert

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